Using the mouse
Right-click a pane for its menu, click rows in lists and tables, and click the hints at the bottom of a panel.
Everything in the terminal UI works from the keyboard, and most of it also works with the mouse, as long as your terminal passes mouse events through. Almost every modern terminal does.
The pane menu
Right-click a pane to open its menu: split it, close it, and the other things you would otherwise reach with the prefix. Hover to move the highlight and click to choose.
Lists and tables
Rows highlight under the pointer and a click selects them. That holds for tables, file lists, the palette, and panels.
Hints are buttons
The hint row at the bottom of a panel, the one that says ⏎ next or esc skip,
is a row of buttons. Click one instead of pressing its key.
Selecting text
Dragging over a pane selects text and copies it, the same as copy mode.